abstract：:Viral myocarditis is a cardiac disease caused by Group B Coxsackie virus of Enterovirus genus in the Picorna viridae family. It causes heart failure in children, young and adults. Ten Percent (10%) of acute heart failure and 12% of sudden deaths in young and adults who are less than 40 years is due to this viral myoca...

journal_title：Current drug targets

authors： Daba TM,Zhao Y,Pan Z

更新日期：2019-01-01 00:00:00

abstract：:Hypertension is usually associated with deficient nitric oxide (NO) bioavailability, and therefore stimulating NO activity is an important antihypertensive strategy. Recently, many studies have shown that both nitrite and nitrate anions are not simple products of NO metabolism and indeed may be reduced back to NO. Whi...

journal_title：Current drug targets

authors： Oliveira-Paula GH,Tanus-Santos JE

更新日期：2019-01-01 00:00:00

abstract：:Breast Cancer (BC) is the most common cancer among women and the second cause of female death for cancer. When the tumor is not correctly eradicated, there is a high relapse risk and incidence of metastasis. Breast Cancer Stem Cells (BCSCs) are responsible for initiating tumors and are resistant to current anticancer ...

journal_title：Current drug targets

authors： Polonio-Alcalá E,Rabionet M,Ruiz-Martínez S,Ciurana J,Puig T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Some kinds of cations and anions are contained in body fluids such as blood, interstitial fluid, gastrointestinal juice, and tears at relatively high concentration. Ionresponsive drug delivery is available to design the unique dosage formulations which provide optimized drug therapy with effective, safe and ...

journal_title：Current drug targets

authors： Yoshida T,Shakushiro K,Sako K

更新日期：2018-02-08 00:00:00

abstract：:Nicotine is one of the most abused substances worldwide and can cause several harmful effects on health. One of the harmful effects, which is often ignored, is osteoporosis. Smoking has been shown to cause a decrease in bone mineral density in humans. Animal studies have proven that nicotine exerts negative effects on...

journal_title：Current drug targets

authors： Mohamed N,Muhammad N,Shuid AN,Soelaiman IN

更新日期：2018-01-01 00:00:00

abstract：:Post-translational modification represents an important mechanism to regulate protein function in cardiac cells. Ubiquitin (Ub) and ubiquitin-like proteins (UBLs) are a family of protein modifiers that share a certain extent of sequence and structure similarity. Conjugation of Ub or UBLs to target proteins is dynamica...

journal_title：Current drug targets

authors： Li J,Johnson JA,Su H

更新日期：2018-01-01 00:00:00

abstract：:Pancreatic cancer is predicted to be the second deadliest malignancy (a median survival of 4-6 months and a 5-year survival of less than 5%) in the USA by 2020. Although current medical detection technologies have dramatically improved the survival rate for patients with other gastrointestinal malignancies, the dismal...

journal_title：Current drug targets

authors： Barton LA,Ren J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Thymoquinone (TQ) is a bioactive phytoconstituent obtained from Nigella sativa (black seeds). It has promising potential in cancer prevention. OBJECTIVE:Previous studies have shown that TQ can modulate signaling pathways responsible for cancer progression, thus enhancing the efficacy and improving the safet...

journal_title：Current drug targets

authors： Barkat MA,Harshita,Ahmad J,Khan MA,Beg S,Ahmad FJ

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Osteosarcoma is considered the most frequent primary bone malignancy. Lung metastasis is the leading cause of death and the most consistent factor for predicting negative patient outcome in osteosarcoma. Third-generation nitrogen-containing bisphosphonates, such as zoledronic acid, have been shown to reduce ...

journal_title：Current drug targets

authors： Ouyang Z,Li H,Zhai Z,Xu J,Dass CR,Qin A,Dai K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The mitochondria may very well determine the final commitment of the cell to death, particularly in times of energy stress. Cancer chemotherapeutics such as the anthracycline doxorubicin perturb mitochondrial structure and function in tumour cells, as evidenced in osteosarcoma, for which doxorubicin is used ...

journal_title：Current drug targets

authors： Armstrong J,Dass CR

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Adipose tissue plays a role in the storage of excess energy as triglycerides (TGs). Excess fat accumulation causes various metabolic and cardiovascular diseases. It has been reported that ectopic fat deposition and excess TG accumulation in non-adipose tissue might be important predictors of cardiometabolic ...

journal_title：Current drug targets

authors： Kugo H,Moriyama T,Zaima N

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Nanotechnology deals with the manufacturing of materials at the atomic and molecular scale. According to the National Nanotechnology Initiative, nanotechnology denotes those structures which are nearly in 1-100 nm size regime in at least one dimension. OBJECTIVE:Nanotechnology in drug delivery has been evid...

journal_title：Current drug targets

authors： Jain A,Kumari R,Tiwari A,Verma A,Tripathi A,Shrivastava A,Jain SK

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a debilitating disease characterized by bone micro-architecture degradation contributing to fragility fractures. Currently, determining bone mineral density (BMD) via dual-energy X-ray absorptiometry (DXA) is the most reliable form of diagnosing osteoporosis and managing pharmacological treat...

journal_title：Current drug targets

authors： Kwon S,Wang AH,Sadowski CA,Yuksel N,Doschak MR

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Prohibitin (PHB) is overtly conserved evolutionarily and ubiquitously expressed protein with pleiotropic functions in diverse cellular compartments. However, regulation and function of these proteins in different cells, tissues and in various diseases is different as evidenced by expression of these proteins...

journal_title：Current drug targets

authors： Chowdhury D,Kumar D,Sarma P,Tangutur AD,Bhadra MP

更新日期：2017-11-30 00:00:00

abstract：:Diabetes is reaching epidemic proportions worldwide. Many dietary compounds have been found to exert health beneficial effects against different pathologies including diabetes. Most bioactive compounds have been identified in fruits and vegetables and their mechanisms of action explored both in vitro and in vivo. In p...

journal_title：Current drug targets

authors： Turrini E,Ferruzzi L,Fimognari C

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Intracranial hemorrhage is characterized by the blood vessel rupture and subsequent hematoma expansion. It is the least treatable stroke subtype, resulting in higher morbidity and mortality per incidence than ischemic stroke. Recent studies have observed lower than normal levels of plasma fibrinogen in patie...

journal_title：Current drug targets

authors： McBride D,Tang J,Zhang JH

更新日期：2017-01-01 00:00:00

abstract：:The development of novel T cell therapies to target leukemia has facilitated the translation of this approach for hematologic malignancies. Different methods of manufacturing leukemia-specific T cells have evolved, along with additional measures to increase the safety of this therapy. This is an overview of expanded T...

journal_title：Current drug targets

authors： Cruz CR,Bollard CM

更新日期：2017-01-01 00:00:00

abstract：:Immune-based inflammatory diseases involve immune related dysregulation in different sites of body, which includes rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, atherosclerosis, etc. Advancements in molecular research have facilitated investigation of their pathogenesis that is involved in infl...

journal_title：Current drug targets

authors： Rahman M,Beg S,Verma A,Kazmi I,Patel DK,Anwar F,Al Abbasi FA,Kumar V

更新日期：2017-01-01 00:00:00

abstract：:Due to potential health benefits and the general assumption that natural products are safe, there is an increasing trend in the general population - including pregnant women - to supplement their diet with flavonoid-based food supplements. In addition, preclinical studies aim to prevent developmental adverse effects i...

journal_title：Current drug targets

authors： Barenys M,Masjosthusmann S,Fritsche E

更新日期：2017-01-01 00:00:00

abstract：:Multi-target drugs against particular multiple targets get better protection, resistance profiles and curative influence by cooperative rules of a key beneficial target with resistance behavior and compensatory elements. Computational techniques can assist us in the efforts to design novel drugs (ligands) with a prefe...

journal_title：Current drug targets

authors： Abdolmaleki A,Ghasemi JB,Ghasemi F

更新日期：2017-01-01 00:00:00

abstract：:The use of imatinib, second and third generation ABL tyrosine kinase inhibitors (TKI) (i.e. dasatinib, nilotinib, bosutinib and ponatinib) made CML a clinically manageable and, in a small percentage of cases, a cured disease. TKI therapy also turned CML blastic transformation into a rare event; however, disease progre...

journal_title：Current drug targets

authors： Perrotti D,Silvestri G,Stramucci L,Yu J,Trotta R

更新日期：2017-01-01 00:00:00

abstract：:Escalating resistance to almost every class of antibiotics is reducing the utility of currently available antimicrobial drugs. A part of this menace is attributed to poor pharmacokinetics and pharmacodynamics of the drug. Improvement in drug delivery is the most challenging task encountered by the pharmaceutical indus...

journal_title：Current drug targets

authors： Jamil B,Bokhari H,Imran M

更新日期：2017-01-01 00:00:00

abstract：:Bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (CF) patients. In early childhood, the respiratory infections are due to Staphylococcus aureus and Haemophilus influenzae. In older CF patients, pathogenic Gram-negative bacteria like Achromobacter xylosoxidans, Burkh...

journal_title：Current drug targets

authors： Velikova N,Wells JM

更新日期：2017-01-01 00:00:00

abstract：:Immunity is a balanced status with adequate biological defenses to recognize and fight "non-self", as well as adequate tolerance to recognize "self". To maintain this immune homeostasis, a well-organized T cell immune network is required, which in part depends on the well-controlled development of alternative effector...

journal_title：Current drug targets

authors： Liu HX,Jiang A,Chen T,Qu W,Yan HY,Ping J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Recently, there are scientific attempts to discover new drugs in the biotechnology industry in order to treat various diseases including atherosclerosis. OBJECTIVE:The main objective of the present review was to highlight the cellular, molecular biology and inflammatory process related to the atheromatous p...

journal_title：Current drug targets

authors： Thent ZC,Chakraborty C,Mahakkanukrauh P,Nik Ritza Kosai Nik Mahmood N,Rajan R,Das S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Global death rate due to cardiovascular diseases (CVDs) is highest as compared to other ailments. Principal risk factor associated with CVDs is hypertension. Major classes of current antihypertensive (AHT) therapies include angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs)...

journal_title：Current drug targets

authors： Niaz T,Hafeez Z,Imran M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease, a neurodegenerative disorder, is characterized by accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles and loss of cholinergic neurons. LITERATURE REVIEW:The localization of Aβ plaques particularly in the cholinergic neuron-rich areas has led to the discovery that Aβ binds...

journal_title：Current drug targets

authors： Farhat SM,Ahmed T

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The plant milk thistle and silymarin has been traditionally used as a natural remedy for the treatment of various ailments including neurological disorders such as Alzheimer's and Parkinson's disease and cerebral ischemia for over 2000 years. OBJECTIVE:In this article we review the neuroprotective effects o...

journal_title：Current drug targets

authors： Devi KP,Malar DS,Braidy N,Nabavi SM,Nabavi SF

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The intracellular multiprotein complex termed the inflammasome functions as a platform of pro-inflammatory cytokine production such as IL-1β and IL-18. Under certain conditions, however, the inflammasome produces non-canonical effects such as induction of cell death, pyroptosis and cell metabolism alteration...

journal_title：Current drug targets

authors： Conley SM,Abais JM,Boini KM,Li PL

更新日期：2017-01-01 00:00:00

abstract：:Prostaglandins serve as the connecting link between inflammation and cancer. mPGES1, the downstream enzyme in the prostaglandin pathway is considered a better target than COX-2 against the progression of cancer due to the cardiovascular and other complications associated with the inhibition of the latter. Despite the ...

journal_title：Current drug targets

authors： Ramanan M,Doble M

更新日期：2017-01-01 00:00:00

abstract：:Acute myeloid leukemia (AML) was the first malignancy for which immunotherapy, in the form of allogeneic hematopoietic stem cell transplantation (allo-HSCT), was integrated into the standard of care. Allo-HSCT however is an imperfect therapy associated with significant morbidity and mortality while offering only incom...

journal_title：Current drug targets

authors： Goswami M,Hourigan CS

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Preeclampsia, a gestational disease characterized by hypertension and proteinuria twenty weeks into pregnancy, is one of the leading causes of fetal and maternal mortality. Although multiple genetic and environmental factors are found to be related to the preeclampsia risk, the pathogenic pathways remain lar...

journal_title：Current drug targets

authors： Song X,Luo X,Gao Q,Wang Y,Gao Q,Long W

更新日期：2017-01-01 00:00:00

abstract：:Phytometabolites are functional elements derived from plants and most of them exhibit therapeutic characteristics such as anti-cancer, anti-inflammatory and anti-oxidant effects. Phytometabolites exert their anti-cancer effect by targeting multiple signaling pathways. One of the remarkable phenomena targeted by phytom...

journal_title：Current drug targets

authors： Hasanpourghadi M,Looi CY,Pandurangan AK,Sethi G,Wong WF,Mustafa MR

更新日期：2017-01-01 00:00:00

abstract：:As early as 1940, Abraham and Chain described "an enzyme able to destroy penicillin". In the late 1940's, penicillin-resistant strains of Staphylococcus aureus were found to be a clinical problem. They produced a penicillinase that could hydrolyze the amide bond in the β-lactam ring. Later, an enzyme mediated by an R-...

journal_title：Current drug targets

authors： Frère JM,Sauvage E,Kerff F

更新日期：2016-01-01 00:00:00

abstract：:Lung cancer kills approximately 1.3 million citizens in the world annually. The tyrosine kinase inhibitors (TKI) erlotinib and gefitinib are effective anti-tumor agents especially in lung cancer patients with epidermal growth factor receptor (EGFR) mutations. The goal is to increase the potency of TKI in lung cancer p...

journal_title：Current drug targets

authors： Moody TW,Nuche-Berenguer B,Nakamura T,Jensen RT

更新日期：2016-01-01 00:00:00

abstract：:Despite the success of combined antiretroviral therapy, more than half of HIV-1-infected patients in the USA show HIV-associated neurological and neuropsychiatric deficits. This is accompanied by anatomical and functional alterations in vulnerable brain regions of the mesocorticolimbic and nigrostriatal systems that r...

journal_title：Current drug targets

authors： Hu XT

更新日期：2016-01-01 00:00:00

abstract：:Protein-protein interactions (PPIs) play important roles in a variety of biological processes, and many PPIs have been regarded as biologically compelling targets for drug discovery. Extensive efforts have been made to develop feasible proteinprotein docking approaches to study PPIs in silico. Most of these approaches...

journal_title：Current drug targets

authors： Zhang Q,Feng T,Xu L,Sun H,Pan P,Li Y,Li D,Hou T

更新日期：2016-01-01 00:00:00

abstract：:Epidemiological studies provide a growing number of evidences that chronic exposure to relatively low levels of cadmium (Cd), nowadays taking place in industrialized countries, may cause health hazard. Thus, growing interest has been focused on effective ways of protection from adverse effects of exposure to this heav...

journal_title：Current drug targets

authors： Brzóska MM,Borowska S,Tomczyk M

更新日期：2016-01-01 00:00:00

abstract：:The androgen receptor (AR) signalling pathway remains a key driver of prostate cancer progression despite castrate levels of testosterone in advanced disease. The androgen biosynthesis inhibitor abiraterone and the anti-androgen enzalutamide have been shown to prolong survival in randomized clinical trials both pre-an...

journal_title：Current drug targets

authors： Assi R,Temraz S,Shamseddine A,Mukherji D

更新日期：2016-01-01 00:00:00

abstract：:The production of reactive oxygen species is a normal part of cell physiology, but many internal and external stimuli are able to trigger the production of excess levels of oxidants that are potentially damaging. The threat of oxidative damage is particularly significant to DNA, as damaged bases can interfere with rep...

journal_title：Current drug targets

authors： Shaukat Z,Liu D,Hussain R,Khan M,Gregory SL

更新日期：2016-01-01 00:00:00